The hematologist reviewed Steven's case, and recommended that he be treated with recombinant factor VIII. Steven's doctor explained that in the past, the hemophilia population was largely affected by blood borne viruses, especially the hepatitis viruses and HIV. Although more expensive, this genetically engineered replacement product virtually eliminates the risk of blood borne viruses.

 

See Hemophilia Methods of Treatment

 

See Workbook 8-18, "Recombinant DNA Technology"

 

21. Why were males with hemophilia at such great risk for acquiring AIDS and other blood borne viruses in the 1980's?

22. How have researchers helped to alleviate the problem of viral contamination?

23. How is recombinant DNA made?

24. What is gene therapy? Why is this looked at as a possible cure for hemophilia?

25. How does gene therapy work?

26. What is the current status of gene therapy research?

 

The hematologist recommended that Steven's parents make an appointment with a genetic counselor. The counselor could help them piece together the family history, and identify other siblings whose children may be at risk.

 

Instructor's Note: At this point it would be helpful to review the following links reviewing basic genetics and genetic testing:
Understanding Gene Testing This is an excellent "booklet" describing basic genetic principles as well as information about genetic testing. Links to subsequent pages of the booklet are included at the bottom of each page.
X-linked recessive genetic defects

 

Also review the Case Study Workbook, pgs. 8-10--8-16.

 

Just for fun: 18 Things You Should Know About Genetics

 

 

 

X Linked Recessive

 

 

 

27. What is a gene?

28. What is DNA?

29. What is a chromosome?

30. How are genes linked to disease?

31. What is the difference between hereditary and acquired mutations?

32. What is an allele, a dominant allele, and a recessive allele?

33. What is a carrier?

34. What is gene testing?

35. What is a predictive gene test?

36. Bob Smith does not have hemophilia but his brother does. Can Bob's children inherit the disease?

37. Jim Smith (Bob's brother) has hemophilia. Can his sons inherit the disease?