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The
hematologist reviewed Steven's case, and recommended that he be
treated with recombinant factor VIII. Steven's doctor
explained that in the past, the hemophilia population was largely
affected by blood borne viruses, especially the hepatitis viruses
and HIV. Although more expensive, this genetically
engineered replacement product virtually eliminates the risk of
blood borne viruses.
See
Hemophilia
Methods of Treatment
See Workbook Module 5, "Recombinant DNA Technology"
21.
Why were males with hemophilia at such great risk for acquiring
AIDS and other blood borne viruses in the 1980's?
22.
How have researchers helped to alleviate the problem of viral
contamination?
23. How is recombinant DNA made?
24.
What is gene therapy? Why is this looked at as a possible
cure for hemophilia?
25. How does gene therapy work?
26. What is the current status of gene therapy research?
The
hematologist recommended that Steven's parents make an
appointment with a genetic counselor. The counselor could
help them piece together the family history, and identify other
siblings whose children may be at risk.
Instructor's
Note: At
this point it would be helpful to review the following links
reviewing basic genetics and genetic testing:
Understanding
Gene Testing
This is an excellent "booklet" describing basic genetic
principles as well as information about genetic testing.
Links to subsequent pages of the booklet are included at the
bottom of each page.
X-linked recessive genetic defects
27.
What is a gene?
28. What is DNA?
29. What is a
chromosome?
30. How are genes linked to disease?
31.
What is the difference between hereditary and acquired
mutations?
32. What is an allele, a dominant allele, and
a recessive allele?
33. What is a carrier?
34.
What is gene testing?
35. What is a predictive gene
test?
36. Bob Smith does not have hemophilia but his
brother does. Can Bob's children inherit the disease?
37.
Could Bob's brother's sons also have hemophilia?
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